Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques.
Identifieur interne : 001F48 ( Main/Exploration ); précédent : 001F47; suivant : 001F49Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques.
Auteurs : Emmie De Wit [États-Unis] ; Angela L. Rasmussen ; Darryl Falzarano ; Trenton Bushmaker ; Friederike Feldmann ; Douglas L. Brining ; Elizabeth R. Fischer ; Cynthia Martellaro ; Atsushi Okumura ; Jean Chang ; Dana Scott ; Arndt G. Benecke ; Michael G. Katze ; Heinz Feldmann ; Vincent J. MunsterSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Excrétion virale (physiologie), Macaca mulatta, Maladies transmissibles émergentes (virologie), Microscopie électronique à transmission, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Réplication virale (physiologie), Spécificité d'espèce, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virion (ultrastructure).
- MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- physiologie : Excrétion virale, Réplication virale.
- virologie : Maladies transmissibles émergentes, Poumon, Syndrome respiratoire aigu sévère.
- ultrastructure : Animaux, Macaca mulatta, Microscopie électronique à transmission, Modèles animaux de maladie humaine, Spécificité d'espèce, Virion.
English descriptors
- KwdEn :
- Animals, Communicable Diseases, Emerging (virology), Disease Models, Animal, Lung (pathology), Lung (virology), Macaca mulatta, Microscopy, Electron, Transmission, Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Species Specificity, Virion (ultrastructure), Virus Replication (physiology), Virus Shedding (physiology).
- MESH :
- pathology : Lung, Severe Acute Respiratory Syndrome.
- physiology : Virus Replication, Virus Shedding.
- ultrastructure : Virion.
- virology : Communicable Diseases, Emerging, Lung, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Macaca mulatta, Microscopy, Electron, Transmission, Species Specificity.
- mix :
Abstract
In 2012, a novel betacoronavirus, designated Middle East respiratory syndrome coronavirus or MERS-CoV and associated with severe respiratory disease in humans, emerged in the Arabian Peninsula. To date, 108 human cases have been reported, including cases of human-to-human transmission. The availability of an animal disease model is essential for understanding pathogenesis and developing effective countermeasures. Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 10(6) 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection. Clinical signs, virus shedding, virus replication in respiratory tissues, gene expression, and cytokine and chemokine profiles peaked early in infection and decreased over time. MERS-CoV caused a multifocal, mild to marked interstitial pneumonia, with virus replication occurring mainly in alveolar pneumocytes. This tropism of MERS-CoV for the lower respiratory tract may explain the severity of the disease observed in humans and the, up to now, limited human-to-human transmission.
Url:
DOI: 10.1073/pnas.1310744110
PubMed: 24062443
Affiliations:
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Le document en format XML
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Rasmussen</name></author><author><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name></author><author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name></author><author><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name></author><author><name sortKey="Brining, Douglas L" sort="Brining, Douglas L" uniqKey="Brining D" first="Douglas L" last="Brining">Douglas L. Brining</name></author><author><name sortKey="Fischer, Elizabeth R" sort="Fischer, Elizabeth R" uniqKey="Fischer E" first="Elizabeth R" last="Fischer">Elizabeth R. 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Katze</name></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name></author><author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Communicable Diseases, Emerging (virology)</term><term>Disease Models, Animal</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Microscopy, Electron, Transmission</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Species Specificity</term><term>Virion (ultrastructure)</term><term>Virus Replication (physiology)</term><term>Virus Shedding (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Excrétion virale (physiologie)</term><term>Macaca mulatta</term><term>Maladies transmissibles émergentes (virologie)</term><term>Microscopie électronique à transmission</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Réplication virale (physiologie)</term><term>Spécificité d'espèce</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virion (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Excrétion virale</term><term>Réplication virale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Virus Replication</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Virion</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies transmissibles émergentes</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Macaca mulatta</term><term>Microscopy, Electron, Transmission</term><term>Species Specificity</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Animaux</term><term>Macaca mulatta</term><term>Microscopie électronique à transmission</term><term>Modèles animaux de maladie humaine</term><term>Spécificité d'espèce</term><term>Virion</term></keywords><keywords scheme="mix" xml:lang="en"><term> DPP4</term><term>emerging infectious disease</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2012, a novel betacoronavirus, designated Middle East respiratory syndrome coronavirus or MERS-CoV and associated with severe respiratory disease in humans, emerged in the Arabian Peninsula. To date, 108 human cases have been reported, including cases of human-to-human transmission. The availability of an animal disease model is essential for understanding pathogenesis and developing effective countermeasures. Upon a combination of intratracheal, ocular, oral, and intranasal inoculation with 7 × 10(6) 50% tissue culture infectious dose of the MERS-CoV isolate HCoV-EMC/2012, rhesus macaques developed a transient lower respiratory tract infection. Clinical signs, virus shedding, virus replication in respiratory tissues, gene expression, and cytokine and chemokine profiles peaked early in infection and decreased over time. MERS-CoV caused a multifocal, mild to marked interstitial pneumonia, with virus replication occurring mainly in alveolar pneumocytes. This tropism of MERS-CoV for the lower respiratory tract may explain the severity of the disease observed in humans and the, up to now, limited human-to-human transmission. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Montana</li></region></list><tree><noCountry><name sortKey="Benecke, Arndt G" sort="Benecke, Arndt G" uniqKey="Benecke A" first="Arndt G" last="Benecke">Arndt G. Benecke</name><name sortKey="Brining, Douglas L" sort="Brining, Douglas L" uniqKey="Brining D" first="Douglas L" last="Brining">Douglas L. Brining</name><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name><name sortKey="Chang, Jean" sort="Chang, Jean" uniqKey="Chang J" first="Jean" last="Chang">Jean Chang</name><name sortKey="Falzarano, Darryl" sort="Falzarano, Darryl" uniqKey="Falzarano D" first="Darryl" last="Falzarano">Darryl Falzarano</name><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Fischer, Elizabeth R" sort="Fischer, Elizabeth R" uniqKey="Fischer E" first="Elizabeth R" last="Fischer">Elizabeth R. Fischer</name><name sortKey="Katze, Michael G" sort="Katze, Michael G" uniqKey="Katze M" first="Michael G" last="Katze">Michael G. Katze</name><name sortKey="Martellaro, Cynthia" sort="Martellaro, Cynthia" uniqKey="Martellaro C" first="Cynthia" last="Martellaro">Cynthia Martellaro</name><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><name sortKey="Rasmussen, Angela L" sort="Rasmussen, Angela L" uniqKey="Rasmussen A" first="Angela L" last="Rasmussen">Angela L. Rasmussen</name><name sortKey="Scott, Dana" sort="Scott, Dana" uniqKey="Scott D" first="Dana" last="Scott">Dana Scott</name></noCountry><country name="États-Unis"><region name="Montana"><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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